![]() For detailed information on billing and cancelation, please visit the Hulu Help Center ( ). Location data may be required to watch certain content. Access content from each service separately. Offer valid for eligible subscribers, devices, and billing partners. Includes certain combinations of Disney+, Hulu, and ESPN+, subject to change. Please review our Terms of Use ( ) and Privacy Policy ( ). Pricing, channels, features, content, and compatible devices subject to change. Number of permitted concurrent streams will vary based on the terms of your subscription. Programming subject to regional availability, blackouts, and device restrictions. Watch free online television channels from the Unites States (US / USA). Click here to check channel availability in your area. Live TV may vary by subscription and location. Location data required to access content. Inflight entertainment is free when you fly with Southwest Connect to the portal through WiFi to access free movies, free live TV, and inflight drink. Streaming content may count against your data usage. Multiple concurrent streams and HD content may require higher bandwidth. Compatible device and high-speed, broadband Internet connection required. Live TV is available in the 50 United States and the District of Columbia only. Stream live TV from ABC, CBS, FOX, NBC, ESPN & popular cable networks in English and Spanish. For personal and non-commercial use only. Any free trials valid for new and eligible returning subscribers only. 7.Īll 16 teams that make it to the knockouts will be dreaming of advancing all the way to the final which will be held at the Ataturk Olympic Stadium in Istanbul, Turkey on June 10, 2023.18+ only. The teams that finish in first place will be drawn against teams that finish in second place in a draw that takes place on Nov. With ZEE5, watch your favourite TV shows, news, movies & entertainment videos live in Hindi, English other regional languages. The top two teams from each Champions League group advance to the knockout rounds, beginning with the Round of 16. Enjoy 90+ Live TV channels online only on ZEE5 in HD. All six rounds will be completed by November 2, just before the break for the 2022 World Cup. The 2022-2023 Champions League season features a 32-team group stage with every team playing six matches. How to listen to Aston Villa vs Arsenal for free. ![]() MORE: Champions League prize money breakdown for 2022/23 Champions League schedule 2022-2023 In Spanish: Univision places select matches across its TV networks (Univision, TUDN, UniMas, and Galavision) and those televised matches are also streamed on fuboTV.įor the first time, a Spanish-language stream will be available for every match on ViX+ (subscription only), with select matches streaming for free on ViX.com. The Genesis Invitational will resume on Saturday afternoon at the beautiful Riviera Country Club in Pacific Palisades, CA. The Golazo Show, streamed on Paramount+ and televised on CBS Sports Network, is a whiparound show that features live updates from all the matches as they happen. ![]() Those select televised matches will also stream on fuboTV. ![]() In English: CBS streams every match on Paramount+ for subscribers, with select matches televised on CBS or CBS Sports Network. The Champions League is carried by CBS (English) and Univision (Spanish) in the USA. Though free to download, the app does require a subscription with one of the pay TV providers listed above to stream live games, shows, and other sports content. Enjoy 90+ Live TV channels online only on ZEE5 in HD. What channel is Champions League on in USA MORE: Updated UEFA Champions League top scorers for 2022/23 Round of 16 - 1st Legs Date One week later we'll get the grudge match from the 2022 Champions League final as Liverpool get a chance to exact some revenge against Real Madrid. The Round of 16 gets underway with one of the biggest matchups on the docket as PSG and Bayern Munich lock horns in a meeting of tournament favorites. MORE: Final Champions League group standings How to watch Champions League in USA Meanwhile, Belgium (Club Brugge) is represented by as many clubs as Spain (Real Madrid) and France (PSG). There are four teams from both England and Germany in the Round of 16. Stream live TV from ABC, CBS, FOX, NBC, ESPN & popular cable networks in English and Spanish. The eight teams left standing after the Round of 16 will be part of the quarterfinal draw in March. With Liverpool, PSG, Borussia Dortmund, and AC Milan all finishing in second place in their group, it made for some interesting matchups. The draw matched up group stage winners against group runners-up. The final 16 teams will begin to do battle for a place in the quarterfinals as the knockout stage gets underway with the Round of 16. ![]()
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![]() While many readers have loved the from-scratch recipe, several of you struggled to get the pie set. Originally this recipe was posted with the egg yolk version and was later updated to include the whole egg version. I’ve made it several ways including from scratch with egg yolks, from scratch with whole eggs and an easy shortcut recipe. This dessert is best made ahead of time making it the perfect holiday treat!īanana cream pie is a staple in my kitchen (along with a classic apple pie). It’s all topped off with whipped topping. A flaky pie crust is filled with fresh bananas and a rich creamy vanilla layer. Dollop the pie with the whipped cream, then slice and serve.Banana Cream Pie is an old-fashioned pie that everyone loves. Whisk with an electric mixer on medium-high speed until stiff peaks form, 2 to 4 minutes. Combine the heavy cream and confectioners sugar in a large bowl. Step 6 For serving: Slice the remaining two bananas to decorate the top of the pie.Refrigerate to cool completely, about 6 hours. Press plastic wrap into the top of the pie to completely cover the filling. Whisk the filling well then pour it into the pie crust and smooth the top. Step 5 Slice two of the bananas and spread them into an even layer over the base of the pie crust.Transfer to a medium bowl and press plastic wrap into the surface (to prevent a film from forming). Add the butter and stir until everything is combined. Bring to a simmer and cook for 1 minute while it bubbles, whisking constantly, then remove it from the heat. Transfer the yolk mixture back to the pot and whisk to combine. Step 4 Remove 1 cup of the half and half mixture and slowly drizzle it into the egg yolks, while whisking constantly.(Scrape the bottom and corners of the pot with a rubber spatula periodically, to make sure nothing gets stuck.) Remove from the heat. Cook until thickened, whisking constantly, 6 to 8 minutes. Step 3 Place the half and half mixture over medium heat.Whisk the egg yolks in a separate medium bowl. Step 2 For the filling: Whisk together the sugar and cornstarch in a medium saucepan.Return to the oven and bake until the whole crust is golden brown all over, 13 to 15 minutes longer. Remove the pie weights and parchment paper and prick the bottom of the crust with a fork, 6 to 8 times. Bake for 16 to 18 minutes, until the edges of the crust are very lightly golden. Line the inside of the crust with parchment paper, then fill with baking weights or dried beans. Place the crust in the refrigerator for 1 hour (or freezer for 30 minutes). Tuck the edges of the crust under to be even with the edge of the pie plate and crimp the edges as desired. Transfer the crust to a 9-inch-deep dish pie plate. Roll the pie dough into a 13-inch circle on a lightly floured surface. Step 1 For the crust: Preheat the oven to 400˚.Refrigeration is also required to allow the filling to set up and make the pie sliceable. Yes, because the filling of banana cream pie contains dairy (eggs and half and half), it needs to be refrigerated after cooking. Once chilled, this should keep your banana cream pie from being runny. When cooking the filling, it is important to cook it at a low boil, in order to activate the corn starch and heat the egg yolks to a temperature that they will adequately thicken the custard. Vanilla pudding could be used in its place but is softer in texture and make the pie more difficult to slice. It is cooked similarly to a pudding, but the technique behind it cooks the eggs differently and allows the filling to set up for easy slicing. This banana cream pie recipe includes a custard filling that is made like a pastry cream. Either cut and place these right before serving the pie, or if the pie will be sitting on a Thanksgiving dessert spread-try this trick to keep them from turning brown. This is most important for the bananas that go on top of the pie. If using lemon or lime juice, dilute it with a small amount of water so the bananas won't pick up the flavor of the citrus. Just like an apple, a brush or dip in an acidic liquid will keep the banana slices from turning brown. ![]() How do you keep bananas from turning brown in banana cream pie? With a homemade pie crust, layers of thinly sliced banana, a vanilla custard filling and tons of whipped cream-it's a show-stopping pie recipe worthy of a place in your annual Thanksgiving feast! However, there is certainly someone at your holiday table who would love a slice of banana bread or this banana cream pie. Ree Drummond would agree that banana desserts aren't exactly everyone's favorite. ![]() ![]() ![]() ![]() zelen 6 Home Decor, Interior Designers, Landscape Architects or Designers 515 Balboa St, San Francisco, CA Closed Zenscape 34 Landscaping, Gardening, Landscape Architects or Designers Serving San Francisco and the Surrounding Area Closed Terra Gardens 14 Hiring a landscape designer costs about $4,200 on average. If you want to transform your backyard but you want a cohesive plan first, find a local backyard designer. Located near the local towns of Milton, Ellendale and Greenwood hosting many dinning and eatery favorites like the Dogfish Head Craft Brewery, Southern Grille, Caf Tamburelli’s and Vanderwende Farm Creamery, and a plethora of unique boutiques and antique shops.net CONTACT US Outdoor Makeover & Living Spaces is properly insured, has workman’s comp insurance, and … Hire as soon as you’re ready. Daswing Designs is an award-winning luxury pool … Wauters Design Group, LLC Call Now: (703) 748-0254 Out of Network Envision Landscapes Inc Call Now: (919) 427-3414 Backyards start out as empty lots of grass, but they don't have to stay that way. Best 15 Landscape Architects & Designers Near Me | Houzz Interior Designers & Decorators Architects & Building Designers Design-Build Firms Kitchen & Bathroom Designers General Contractors Kitchen & Bathroom Remodelers Home Builders Roofing & Gutters Cabinets & Cabinetry Tile & Stone Hardwood Flooring Dealers Painters Landscape Contractors Landscape Architects & Landscape Designers 1 – 15 of 308 professionals E. Landscape Contractors & Designers review in Edmonton 2 months ago Highly recommend their services. Our landscape specialists - led by designer John Scott - are experts at creating unique outdoor living spaces in North Texas yards. 5 (20) Offers remote services 62 hires on Thumbtack 1 similar job done near you Online now Hiring a landscape designer costs about $4,200 on average. ![]() From outdoor kitchens to patios and … Custom landscape designers for San Diego homes since 1998. They really love the stuff I get here!" We specialize in helping clients increase the value and beauty of their homes by creating elegant outdoor living spaces. Explore our landscape design projects for homeowners throughout the U. Conveniently located near Mill Ave, Tempe Marketplace, major freeways, the airport, casinos, Old-Town Scottsdale, and spring training events, this home is the perfect blend of location and luxury. I would always buy too many sweets here right before my nieces and nephews come to town. ![]() ![]() Run GeekTool over your desktop to integrate live feeds of things like the weather, Twitter feed, wiki articles, whatever is playing on Spotify and so much more. Unlike the name suggests, you don't need to be a geek to use this tool. When you're already keeping your eyes open late at night, they will thank you for at least using Byword. And the nicest thing about Byword? The naturally dark paper and white text option. Things like grammar and spelling mistakes can be edited later, but the important thing is that you get your ideas down before they escape you. It offers just enough to get your thoughts down, and not enough to be distracting. Byword is the most simple, clean and visually appealing word processing software that I have found on the internet. I realize that this list is supposed to be on free software, but I am writing this on Byword right now so I'm giving it a brief second of limelight. ImageOptim will reduce an image's quality as much as possible before the difference is noticeable to the human eye, and often times this means reducing the file size enough to get past nasty online upload limits. Image quality and image size are two different things, and while it's a difficult concept to explain, it is totally possible to have two images of the same size and same apparent quality, and for one to be half or even a quarter as large in file size. More than just an auto brightness, it reduces the blue colors on your screen as well, which are scientifically shown to make sleeping difficult after being exposed. This will probably become irrelevant soon, as the word is out that Apple will be integrating a similar service in their new OS, but for now, f.lux is a great piece of software that adjusts the color and brightness of your computer screen with the time of day and lighting in the room. In two clicks I can open the corresponding iPhone app and take over the cursor so long as I'm on the same network. I used to use this daily, and still have it open at all times in case I ever find myself in a situation where I need to navigate my computer without it being within reach. Be it a forgotten file in your Downloads or way back under your layers of Desktop Cleanup folders, GrandPerspective will find it. Chances are, you have at least one folder or file taking up excessive amounts of space. If your hard drive is full and you don't know why, GrandPerspective gives you an easy to understand overview of all your files and scales them by their data size. Itsycal, on the other hand, is updated often is works seamlessly. For the longest time, everyone used Day-O, but if you are using the newest version of your Intel operating system, Day-O will prove to be more frustrating than useful, as the developer stopped updating it several years ago. Why Apple didn't add an easy to open Calendar to the menu bar of OS X, I have no idea. ![]() You can find Gif Brewery at their website. Whenever you need to paste something you copied earlier, just scroll through your clipboard history! (Note: I've heard much talk about a more recent progenitor called Fl圜ut, which does the same thing as Jumpcut, but is kept more up to date.) GIF Brewery 3: temporarily freeĪt the time I wrote this, GIF Brewery was free, but even if it isn't still, this is a great app and worth any reasonable price to create GIFs without limitations and watermarks. Download it and adjust the settings so that it saves after each copy, up to 100. I use it hundreds of times a day, and it has saved my fingers countless times. I'm not sure what I would do without Jumpcut. Save up to 100 of the most recent clipboard copies for easy scrolling through later on, and paste at any time. Below I have listed a few of my favorites. ![]() With the continually growing adoption of Mac computers in the office and a stronger demand for software and applications that will increase productivity and efficiency, there has been an increasing supply of free or relatively inexpensive programs for OS X that almost any Mac user could use on a daily basis. ![]() ![]() ![]() So please Karen's, maybe try playing the game for a bit before assuming that its 18 :). I've never seen any problems with skins though. The main problem is the skin customize option. When it comes to skins, there's nothing that bad. You can also disable chat, if your worried about any swearing/inappropriate chat topics. Normally it's the little kids trying to seem cool. I've played with my own friends that I've met and none of them say any swear words. The game itself doesn't include any swearing. You can also earn coins in pixel gun to buy guns but it's hard to win games when there is so many good players. There's really nothing bad about this game except 1 thing. ![]() I've played this game since I was 9 years old. Minecraft is a trademark of Mojang AB and it is not endorsed by or affiliated with the creator of this game or its licensers.Ok Karen's, this game isn't that bad. RiliSoft is not associated or connected with Mojang AB and its game Minecraft – Pocket Edition. Learn how to Install and run Pixel Gun 3D: Survival shooter ![]() If you are having any issues, shoot us an email, Contact MPGH Support. Ads are removed, almost completely ad free browsing. ![]() Let your voice be heard! You can post, reply, and share whatever is on your mind.Active marketplace for gamers and people like you, with thousands of contributors and over half a million posts.Interact with our great community, and make new friends with our members.Free access to tutorials, resources, information, tools, trainers, cheats and hacks.Access to our large gaming community with millions of discussions to participate in.REGISTER now for full benefits of our site, it's completely FREE to join: With several hundred thousand FREE hacks, cheats and bots, over 4 million members strong, a free and open marketplace and a great community, what else is there to ask for? 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Welcome to MPGH - MultiPlayer Game Hacking, the world's leader in Game Hacks, Game Cheats, Trainers, Combat Arms Hacks & Cheats, Crossfire Hacks & Cheats, WarRock Hacks & Cheats, SoldierFront Hacks & Cheats, Project Blackout Hacks & Cheats, Operation 7 Hacks & Cheats, Blackshot Hacks & Cheats, A.V.A.EverwingHax - fully automated character unlock/leveling and sidekick generation. ![]() ![]() Your dad, a former superhero himself, built the training simulator dreaming of your journey to becoming a superhero. This high quality light source provides excellent, on target light output. Sunblaze, with a mission to complete your superhero training. and well be ready to accept students in about six months for the 2023-24. Using the environmentally friendly, mercury-free AgroLED® iSunlight® lamps reduce the electricity consumption by up to 25% compared to traditional T5 lamps. 12 Red Triangle Coal Co 127 Regal gp 91 TT> 108 95 24 113 1 105 55 19 43. At Sun Blaze Elementary School, we work together as partners to ensure every. There is one more shelf included than is pictured that isnt currently installed. Comes with 4 extra new bulbs as well as a steel adjustable shelving unit. It is a very basic setup overall, but it works well for me. Barely used Sunblaze T5 High Output 4 Bulb 24' grow light setup. Ignore the excess moisture in the terrarium (the PC fan takes care of that completely) and the droopy Mimosa pudica, I just turned the light on to get the picture. The “daisy-chain” feature allows multiple fixtures to be plugged in together. Mine is the Hydrofarm equivalent of the Sunblaze fixture, which is basically just a different color. Eight lamp model features two on/off switches to run four lamps at a time if desired. 12 ft power cord and on/off switch allows for easy operation. Wire cable hangers are included with every fixture as well as V-hangers and hanging holes for side mounting (hangs horizontally or vertically) and lower ceilings. ![]() White powder-coated steel housing is louvered for cool operation. Sun Blaze® LED fixtures feature an advanced reflector design that delivers excellent reflectivity and diffusion. These lamps combined produce an amazing 2,400 lumens per lamp for 2 ft and 4,900 lumens per lamp for 4 ft with a 5,500°K lamp color that is ideal for propagation and vegetative lighting cycles. The Sun Blaze T5 LED 24 fixtures come with 41 watt AgroLED iSunlight lamps. ![]() This high-efficiency T5 LED fixture is equipped with 21 watt AgroLED® iSunlight® lamps. ![]() ![]() 2 must avoid seeking external validation and, instead, realize that perfect equilibrium needed already exists within.Ĭommunication is paramount for 3. Because 2 is so sensitive, it is very conflict-averse, and can end up feeling under-appreciated or unacknowledged. ![]() 2 is linked to psychic abilities and intuition, and if this number appears as a Life Path or Destiny Number, the individual will be astute to subtle energy shifts and emotional nuances. Within numerology, the 2 vibration assumes the role of the mediator, creating harmony by bringing together dissonant forces through compassion, empathy, and kindness. The number 2 is linked to sensitivity, balance, and harmony. ![]() Even the most autonomous 1s need the support of their friends, family, and lovers. 1 must remember that although it is first, it can very quickly become the loneliest number. On a bad day, 1 can be a bit bossy or boastful, hiding any insecurities behind over-developed self-importance. 1 symbolizes a pioneering spirit, independent nature, and innate leadership capabilities. Just as Aries, the first sign of the zodiac, is about action and initiation, 1 is linked to forward motion in Numerology. So, now that you've calculated your Life Path Number and Destiny Number, it's time to find out what these digits really mean. That definitely resonates! Which Numerology numbers are most powerful? So, as a Life Path 8 person, my mission is to cultivate abundance, and I will express this through my Destiny Number 6: nurture, healing, and empathy. Whereas your Life Path reveals your greater purpose, your Destiny Number offers insight as to how you will express your greater goals. According to his theories, certain letters have specific numerical values, which are as follows:įor example, my full name reveals my Destiny Number: ALIZA ( 1 + 3 + 9 + 8 + 1 = 22, which becomes 2 + 2 = 4) KELLY ( 2 + 5 + 3 + 3 + 7 = 20, which becomes 2 + 0 = 2), resulting in a Destiny Number of 6 (because 4 + 2 = 7). You can also use numerology to derive the root number of names or words - this is where our ancient buddy Pythagoras offers some guidance. Rather than simplify this to a single digit (yielding 4), the number 22 reflects the Master Number - the higher-octane iteration of 4, revealing McCartney's strong "life mission." How do you calculate your Destiny Number in Numerology? When this date is reduced (month = 6, day = 9, year = 7), the sum is 22. Master Numbers suggest a powerful vibrational energy that is associated with learning, achievement, and success, but likely in a more stressful or higher-stakes context.įor instance, Sir Paul McCartney, perhaps England's most famous Gemini, was born on June 18, 1942. These are considered Master Numbers and connote a more intensified version of their root numbers (2 and 4, respectively). It may seem daunting at first, but once you see it all written out this way, it becomes far less intimidating, right? Right! What are Master Numbers in Numerology?Īs mentioned above, the only time you would not reduce the final number is if you attain 11 or 22. If you were born on August 18, 1989, your Life Path Number is 8 (and you and I also share a birthday!). Then, we add the reduced month, date, and year numbers ( 8 + 9 + 9) and arrive at 26. It’s an ideal place for people who participate in family life or careers that involve filling the role of a caretaker, such as daycare workers, medical professionals, or human services workers.The year, 1989, is reduced to 1 + 9 + 8 + 9. If you were born on a date ruled by the zodiac sign Taurus or Libra, you would do well in such a home. The harmony of the number lends itself well to family life. ![]() If you love to create, you will find plenty of joy when you reside in a house that is numbered 6.ĬOPYRIGHT_SFG: Published on by Calvin Penwell on T11:24:05.000Z Who Is the Numerology House Number 6 For?Ī home with number 6 is a home that you will want to put much care into when considering the home’s aesthetics, as you will come to realize you’re much happier when things are in symmetry and are naturally beautiful.Ĭonsider finding naturally lovely items such as potted plants or unique rocks and displaying them in your home.Ī number 6 home is a great place for you to begin family life, whether you are planning to adopt, are having a multi-generational home, or joyfully expecting a child. ![]() The house of six is a place where love and family thrive and grow. If you have a 6 in your home’s number, or your home numbers add up to 6, such as the case with 33, 51, or 42, you should consider yourself lucky! We offer insights into the type of person best suited to living in a home with number 6 and what it could have in store for you. In this post, we dicuss the meaning of House number 6 numerology. ![]() ![]() I prayed, thanking God for answering my prayers for a job and for opening the doors for this position. The interview went well and the pay was going to be great compared to my college work-study job which paid almost nothing.Īfter the interview, I waited. He was interested in hiring me, I had the qualifications, and we set a date to interview. She encouraged me to apply and then talked to the owner of the small company about me. She was going to stay home with the baby, which meant that her position would be opening up. My girlfriend worked at an educational software company in town and she was about to have a baby. I worked all through high school and college and was a diligent worker with great references. Babysitting, mowing lawns, then working in the laundry room at a nursing home, and summer camp. ![]() I had been working from the time I was about 13. I had just graduated from college and had my shiny new Business Degree under my belt. Thank you! Looking for Scriptures on Disappointment? If you click on a link, I may earn a small commission, at no extra cost to you. Need to build some more hope in your life? Check out our book collection featuring titles from Latter-day Saint authors about overcoming adversity and remaining hopeful in the midst of life's challenges.*Note: This post may contain affiliate links. "Having faith on the Lord having a hope that ye shall receive eternal life having the love of God always in your hearts, that ye may be lifted up at the last day and enter into his rest." “Wherefore, there must be faith and if there must be faith there must also be hope and if there must be hope there must also be charity.” Alma 13:29 "And now as I said concerning faith-faith is not to have a perfect knowledge of things therefore if ye have faith ye hope for things which are not seen, which are true.” “And what is it that ye shall hope for? Behold I say into you that ye shall have hope through the atonement of Christ and the power of his resurrection, to be raised unto life eternal, and this because of your faith in him according to the promise.” Alma 32:21 "All these had departed the mortal life, firm in the hope of a glorious resurrection, through the grace of God the Father and his Only Begotten Son, Jesus Christ." Moroni 7:41 ![]() ![]() “And I also remember that thou hast said that thou hast prepared a house for man, yea, even among the mansions of thy Father, in which man might have a more excellent hope wherefore man must hope, or he cannot receive an inheritance in the place which thou hast prepared.” Doctrine and Covenants 138:14 Wherefore, if ye shall press forward, feasting upon the word of Christ, and endure to the end, behold, thus saith the Father: Ye shall have eternal life.” “Wherefore, ye must press forward with a steadfastness in Christ, having a perfect brightness of hope, and a love of God and of all men. ![]() Behold, I do not bring it to destroy that which they have received, but to build it up." 2 Nephi 31:20 "And now, behold, according to their faith in their prayers will I bring this part of my gospel to the knowledge of my people. “Wherefore, whoso believeth in God might with surety hope for a better world, yea, even a place at the right hand of God, which hope cometh of faith, maketh an anchor to the souls of men, which would make them sure and steadfast, always abounding in good works, being led to glorify God.” Doctrine and Covenants 10:52 “Whosoever shall put their trust in God shall be supported in their trials, and their troubles, and their afflictions, and shall be lifted up at the last day.” Ether 12:4 If we missed one of your favorite scriptures, let us know in the comments section below! Alma 36:3 Scroll through to see 10 inspiring LDS scriptures about hope to help boost your day. Our Father in Heaven is always reaching out to us in love, and one way we can feel of that love is through the scriptures. Some days can feel a little more draining than others, and given the recent events in the world, we could all use a little boost of hope each day. ![]() ![]() ![]() This Small Business Innovation Research Phase II project develops a novel, double-pane window insulated with a sheet of the company?s proprietary super-insulating aerogel. ![]() Phase II work will mature shop optimization software through demonstration in a real aerospace parts factory. The solution demonstrates double digit improvements in all Key Performance Indicators (KPIs), such as on-time delivery (OTD), inventory turns, and profitability. ![]() The business model for delivering this software solution is designed for small and medium size businesses in terms of both cost and usability perspectives. The newly proposed methods, algorithms, and software may solve this challenge. Most scheduling optimizers are unable to handle this problem reliably or affordably. For shops with high product variety, low volume, large lead times, and large set up times, there is a need to find the optimal way to utilize existing resources in order to maximize production rate. This Small Business Innovation Research (SBIR) Phase II project involves the development of a new technology that enables high value manufacturers in optimizing the flow of materials in their shops. The technology may also help strengthen the national defense of the United States by facilitating onshoring of defense manufacturing by making domestic producers more cost competitive. The proposed technology may provide an affordable and easy-to-use solution for target markets in aerospace and medical technologies industries. The application addresses a need to find the optimal way of utilizing existing resources in order to maximize production rates. ![]() The broader impact of this Small Business Innovation Research (SBIR) Phase II project seeks to increase the competitiveness of the US in manufacturing high value parts for shops with high product variety, low volumes, large lead times, and large set up times. This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria. Effective editing will lead to disease correction in both patient cells and mice with no observable off-target editing events. The ErAcr protein will be paired with a novel CRISPR-Cas nuclease and developed into a therapy for SMA> The therapy will be packaged into an adeno-associated viral vector and tested for editing and SMA disease correction in patient-derived cells and in an SMA mouse model. This project will develop an engineered anti-CRISPR (ErAcr) protein to eliminate unintended off-target editing. High precision gene editing technology must be developed to ensure the safety and efficacy of in vivo gene editing therapies. This problem is particularly acute for in vivo therapies where the editing system will be delivered systemically or directly to the target organs, eliminating the ability to screen cells for unwanted editing outcomes. However, application of this technology has been limited by the high degree of unintended 'off-target' editing events. Manipulation of the human genome using CRISPR-Cas gene editors has been validated in early clinical trials to correct genetic diseases. This Small Business Innovation Research (SBIR) Phase II project will develop and validate a curative therapy for spinal muscular atrophy (SMA) using a novel and proprietary CRISPR-Cas precision gene editing system. This technology can be used to improve and even cure patients of genetic disease. The proposed technology will increase the safety and efficacy of gene editing by optimizing the precision of editing to correct the disease. The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be the development of a curative therapy for spinal muscular atrophy using a novel and proprietary precision gene editing technology. ![]() |
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